MISSION
To transform fluorescence-based diagnostics and imaging by leveraging plasmonic nanoantennas—especially DNA-origami templated structures—for ultra-sensitive, fast, and scalable detection of single molecules and biomarkers
CHALLENGES
Precise nanoscale positioning – Achieving sub-10 nm alignment of fluorophores in plasmonic hotspot regions to maximize enhancement while avoiding quenching
Hotspot accessibility and assay integration – Ensuring assay elements can be positioned in hotspots (e.g., via nanoantenna design) without hindrance
Quenching vs. enhancement trade-off – Finding the optimal separation between emitter and metal to maximize radiative enhancement while minimizing non-radiative losses
Scalability and mass production – Transitioning from lab-scale DNA-origami assembly to manufacturable, reproducible devices, potentially via solution-phase synthesis
Low-cost detection platforms – Integrating with accessible imaging systems like smartphone-based microscopes for point-of-care usability
Join us in advancing ultra-sensitive, scalable, and accessible diagnostics through plasmonic fluorescence enhancement—bridging nanotechnology and real-world health applications.